CRISPR–Cas regulates expression of embedded anti-phage defence systems - Nature
Nature (2026) Cite this article Bacteria utilize diverse defence systems to protect against harmful foreign DNA such as bacteriophages1,2, but how these systems coordinate with each other remains poorly understood. Here we uncover CRISIS (CRISPR-supervised immune system), a widespread regulatory paradigm whereby type I CRISPR–Cas loci embed and transcriptionally modulate diverse innate defences.